Publications

Our research has been covered in leading peer-reviewed publications.

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2024

Astrocyte-derived lactate in stress disorders

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Farah Chamaa, Pierre J. Magistretti, Hubert Fiumelli

Neurobiology of Disease

Volume 192, March 2024, 106417

 

 

Publication

2022

Lactate supply overtakes glucose when neural computational and cognitive loads scale up.

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Dembitskaya Y, Piette C, Perez S, Berry H, Magistretti PJ and Venance L.

Proc Natl Acad Sci U S A 2022 Nov 22; 119(47)e2212004119

 

 

Publication

Astrocytes as key regulators of brain energy metabolsim : new therapeutic perspectives.

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Beard E, Lengacher S, Dias S, Magistretti PJ, Finsterwald C.

Front Physiol. 2022 Jan 11;12:825816. doi: 10.3389/fphys.2021.825816. eCollection 2021.

 

Publication

Representing stimulus information in an energy metabolism pathway.

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Coggan JS, Keller D, Markram H, Schürmann F, Magistretti PJ.

J Theor Biol. 2022 May 7;540:111090. doi: 10.1016/j.jtbi.2022.111090. Epub 2022 Mar 7

 

Publication

2021

L-lactate: food for thoughts, memory and behavior

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Veloz Castillo MF, Magistretti PJ, Cali, C,

Metabolites 2021, 11(8), 548; https://doi.org/10.3390/metabo11080548

 

Publication

Digital reconstruction of the neuro-glia-vascular architecture

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Zisis E, Keller D, Kanari L, Arnaudon A, Gevaert M, Delemontex T, Coste B, Foni A, Abdellah M, Calì C, Hess K, Magistretti PJ, Schürmann F, Markram H

Cerebral Cortex, bhab254, https://doi.org/10.1093/cercor/bhab254

 

Publication

Role of adult hippocampal neurogenesis in the antidepressant actions of lactate

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Carrard A, Cassé F, Carron C, Burlet-Godinot S, Toni N, Magistretti PJ; Martin JL,

Mol. Psychiatry 2021, https://doi.org/10.1038/s41380-021-01122-0

 

Publication

Reactive oxygen species: beyond their reactive behavior

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Tauffenberger A, Magistretti PJ

Neurochem Res. 2021 Jan;46(1):77-87. doi: 10.1007/s11064-020-03208-7

 

Publication

Ganglioside GM1 targets astrocytes to stimulate cerebral energy metabolism

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Finsterwald C, Dias S, Magistretti PJ, Lengacher S,

Front. Pharmacol., 28 April 2021 | https://doi.org/10.3389/fphar.2021.653842

 

Publication

Hydroxycarboxylic acid receptor 1 and neuroprotection in a mouse model of cerebral ischemia-reperfusion

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Buscemi L, Blochet C, Magistretti PJ, Hirt L,

Front. Physiol., 21 May 2021 | https://doi.org/10.3389/fphys.2021.689239

 

Publication

2020

Excitation states of metabolic networks predict dose-response fingerprinting and ligand pulse phase signalling

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Coggan JS, Keller D, Markram H, Schurmann F, Magistretti PJ

J Theor Biol. 2020 Feb 21;487:110123. doi: 10.1016/j.jtbi.2019.110123

 

Publication

Ultrastructural evidence for a role of astrocytes and glycogen-derived lactate in learning-dependent synaptic stabilization

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Vezzoli E, Cali C, De Roo M, Ponzoni L, Sogne E, Gagnon N, Francolini M, Braida D, Sala M, Muller D, Falqui A, Magistretti PJ

Cereb Cortex. 2020 Apr 14;30(4):2114-2127. doi: 10.1093/cercor/bhz226.

 

Publication

Gut microbiota modulates expression of genes involved in the astrocyte-neuron lactate shuttle in the hippocampus

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Margineanu M, Sherwin E, Golubeva A, Peterson V, Hoban A, Fiumelli H, Rea K, Cryan JF, Magistretti PJ

European Neuropsychopharmacology, Volume 41, December 2020, Pages 152-159, https://doi.org/10.1016/j.euroneuro.2020.11.006

 

Publication

How lactate links cannabis to social behaviour

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Magistretti PJ

Nature 583, 526-527 (2020); doi: https://doi.org/10.1038/d41586-020-01975-5

 

Publication

2019

Gangliosides: treatment avenues in neurodegenerative disease

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Magistretti PJ, Geisler FH, Schneider JS, Li PA, Fiumelli H, Sipione S

Front Neurol. 2019 Aug 6;10:859. doi: 10.3389/fneur.2019.00859.

 

Publication

3D cellular reconstruction of cortical glia and parenchymal morphometric analysis from serial block-face electron microscopy of juvenile rat

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Cali C, Agus M, Kare K, Boges DJ, Lehvaslaiho H, Hadwiger M, Magistretti PJ

Prog Neurobiol. 2019 Dec;183:101696. doi: 10.1016/j.pneurobio.2019.101696.

 

Publication

Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling

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Tauffenberger A, Fiumelli H, Alsmustafa S, Magistretti PJ

Cell Death Dis. 2019. PMID: 31506428

 

Publication

2018

Peripheral administration of lactate procudes antidepressant-like effect

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Carrard A, Elsayed M, Margineanu M, Boury-Jamot B, Fragniere L, Meylan EM, Petit JM, Fiumelli H, Magistretti PJ, Martin JL.

Mol Psychiatry. 2018 Feb;23(2):488. doi: 10.1038/mp.2016.237. Epub 2016 Dec 6. PMID: 27922608

 

Publication

Lactate in the brain: from metabolic end-product to signalling molecule.

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Magistretti PJ, Allaman I

Nat Rev Neurosci. 2018 Apr;19(4):235-249. doi: 10.1038/nrn.2018.19. PMID: 29515192

 

Publication

Hypertonic lactate to improve cerebral perfusion and glucose availability after acute brain injury

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Carteron L, Solari D, Patet C, Quintard H, Miroz JP, Bloch J, Daniel RT, Hirt L, Eckert P, Magistretti PJ and Oddo M

Crit Care Med. 2018 Jun 19. PMID: 29923931

 

Publication

Hyperpolarized 13C magnetic resonance spectroscopy reveals the rate-limiting role of the blood-brain barrier in the cerebral uptake and metabolism of l-lactate in vivo

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Takado Y, Cheng T, Bastiaasen JAM, Yoshihara HAI, Lanz B, Mishkovsky M, Lengacher S, Comment A

ACS Chem Neurosci. 2018 May 25. doi: 10.1021/acschemneuro.8b00066. PMID: 29771492

 

Publication

Extracellular potassium and glutamate interact to modulate mitochondria in astrocytes

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Rimmele TS, de Castro Abrantes H, Wellbourne-Wood J, Lengacher S, Chatton JY

ACS Chem Neurosci. 2018 Aug 15;9(8):2009-2015. doi: 10.1021/acschemneuro.8b00124. PMID: 29741354

 

Publication

Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate

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Coggan JS, Keller D, Cali C, Lehvaslaiho H, Markram H, Schurmann F, Magistretti PJ

PLoS Comput Biol. 2018 Aug 30;14(8):e1006392. doi: 10.1371/journal.pcbi.1006392. eCollection 2018 Aug. PMID: 30161133

 

Publication

Dual action of L-lactate on the activity of NR2B2-containing NMDA receptors: from potentiation to neuroprotection

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Jourdain P, Rothenfusser K, Ben-Abida C, Allaman I, Marquet P, Magistretti PJ

Sci Rep. 2018 Sep 7;8(1):13472. doi: 10.1038/s41598-018-31534-y. PMID: 30194439

 

Publication

A process for digitizing and stimulating biologically realistic oligocellular networks demonstrated for the neuro-glio-vascular ensemble.

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Coggan JS, Cali C, Keller D, Agus M, Boges D, Abdellah M, Kare K, Lehvaslaiho H, Eilemann S, Jolivet RB, Hadwiger M, Markram H, Schurmann F, Magistretti PJ

Front Neurosci. 2018 Sep 25;12:664. doi: 10.3389/fnins.2018.00664. eCollection 2018. PMID: 30319342

 

Publication

L-lactate regulates the expression of synaptic plasticity and neuroprotection genes in cortical neurons: a transcriptome analysis

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Margineanu MB, Mahmood H, Fiumelli H, Magistretti PJ

Front Mol Neurosci. 2018 Oct 10;11:375. doi: 10.3389/fnmol.2018.00375. eCollection 2018. PMID: 30364173

 

Publication

2017

Inadequate brain glycogen or sleep increases spreading depression susceptibility

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Kilic K, Karatas H, Donmez-Demir B, Eren-Kocak E, Gursoy-Ozdemir Y, Can A, Petit JM, Magistretti PJ, Dalkara T

Ann Neurol. 2017 Dec 15. doi: 10.1002/ana.25122. PMID: 29244233

 

Publication

2016

Lactate release from astrocytes to neurons contributes to cocaine memory formation.

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Boury-Jamot B, Halfon O, Magistretti PJ, Boutrel B.

Bioessays. 2016 Oct 4. doi: 10.1002/bies.201600118.PMID: 27699812

 

Publication

Astrocytic beta 2-adrenergic receptors mediate hippocampal long-term memory consolidation.

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Gao V, Suzuki A, Magistretti PJ, Lengacher S, Pollonini G, Steinman MQ, Alberini CM.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8526-31. doi: 10.1073/pnas.1605063113. Epub 2016 Jul 8.PMID: 27402767

 

Publication

Imaging brain aerobic glycolysis as a marker of synaptic plasticity.

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Magistretti PJ

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7015-6. doi: 10.1073/pnas.1607423113. Epub 2016 Jun 17.PMID: 27317739

 

Publication

A role for lactate in the consolidation of drug-related associative memories.

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Boutrel B, Magistretti PJ.

Biol Psychiatry. 2016 Jun 1;79(11):875-7. doi: 10.1016/j.biopsych.2016.04.010.PMID: 27198521

 

Publication

Sodium signaling and astrocyte energy metabolism.

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Chatton JY, Magistretti PJ, Barros LF.

Glia. 2016 Mar 29. doi: 10.1002/glia.22971.Epub 2016 Mar 29.PMID: 27027636

 

Publication

L-lactate protects neurons against excitotoxicity: implication of an atp-mediated signaling cascade.

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Jourdain P, Allaman I, Rothenfusser K, Fiumelli H, Marquet P, Magistretti PJ.

Sci Rep. 2016 Feb 19;6:21250. doi: 10.1038/srep21250.PMID: 26893204

 

Publication

Regulation of neuron-astrocyte metabolic coupling across the sleep-wake cycle.

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Petit JM, Magistretti PJ.

Neuroscience. 2016 May 26;323:135-56. doi: 10.1016/j.neuroscience.2015.12.007. Epub 2015 Dec 17.PMID: 26704637

 

Publication

Disrupting astrocyte-neuron lactate transfer persistently reduces conditioned responses to cocaine.

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Boury-Jamot B, Carrard A, Martin JL, Halfon O, Magistretti PJ, Boutrel B.

Mol Psychiatry. 2016 Aug;21(8):1070-6. doi: 10.1038/mp.2015.157. Epub 2015 Oct 27.PMID: 26503760

 

Publication

Improvement of neuroenergetics by hypertonic lactate therapy in patients with traumatic brain injury is dependent on baseline cerebral lactate/pyruvate ratio.

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Quintard H, Patet C, Zerlauth JB, Suys T, Bouzat P, Pellerin L, Meuli R, Magistretti PJ, Oddo M.

J Neurotrauma. 2016 Apr 1;33(7):681-7. doi: 10.1089/neu.2015.4057. Epub 2015 Dec 15.PMID: 26421521

 

Publication

In vivo evidence for a lactate gradient from astrocytes to neurons.

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Mächler P, Wyss MT, Elsayed M, Stobart J, Gutierrez R, von Faber-Castell A, Kaelin V, Zuend M, San Martín A, Romero-Gómez I, Baeza-Lehnert F, Lengacher S, Schneider BL, Aebischer P, Magistretti PJ, Barros LF, Weber B.

Cell Metab. 2016 Jan 12;23(1):94-102. doi: 10.1016/j.cmet.2015.10.010. Epub 2015 Nov 19.PMID: 26698914

 

Publication

Lactate release fom astrocytes to neurons contributes to cocaine memory formation

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Boury-Jamot B, Halgon O, Magistretti PJ, Boutrel B

Bioessays. 2016 Dec. doi: 10.1002/bies.201600118. PMID: 27699812

 

Publication

2015

A new outlook on mental illnesses: glial involvement beyond the glue.

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Elsayed M, Magistretti PJ.

Front Cell Neurosci. 2015 Dec 16;9:468. doi: 10.3389/fncel.2015.00468. eCollection 2015. PMID: 26733803

 

Publication

Learning-induced gene expression in the hippocampus reveals a role of neuron -astrocyte metabolic coupling in long term memory.

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Tadi M, Allaman I, Lengacher S, Grenningloh G, Magistretti PJ.

PLoS One. 2015 Oct 29;10(10):e0141568. doi: 10.1371/journal.pone.0141568. eCollection 2015.PMID: 26513352

 

Publication

Astrocytes: new targets for the treatment of neurodegenerative diseases.

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Finsterwald C, Magistretti PJ, Lengacher S.

Curr Pharm Des. 2015;21(25):3570-81. PMID: 26166612

 

Publication

A cellular perspective on brain energy metabolism and functional imaging.

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Magistretti PJ, Allaman I.

Neuron. 2015 May 20;86(4):883-901. doi: 10.1016/j.neuron.2015.03.035. PMID: 25996133

 

Publication

Neuroenergetic response to prolonged cerebral glucose depletion after severe brain injury and the role of lactate.

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Patet C, Quintard H, Suys T, Bloch J, Daniel RT, Pellerin L, Magistretti PJ, Oddo M.

J Neurotrauma. 2015 Oct 15;32(20):1560-6. doi: 10.1089/neu.2014.3781. Epub 2015 May 26.PMID: 25790152

 

Publication

Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush.

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Morrison BM, Tsingalia A, Vidensky S, Lee Y, Jin L, Farah MH, Lengacher S, Magistretti PJ, Pellerin L, Rothstein JD.

Exp Neurol. 2015 Jan;263:325-38. doi: 10.1016/j.expneurol.2014.10.018. Epub 2014 Oct 29.PMID: 25447940

 

Publication

2014

Synaptic plasticity and the warburg effect.

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Magistretti PJ.

Cell Metab. 2014 Jan 7;19(1):4-5. doi: 10.1016/j.cmet.2013.12.012.PMID: 24411936

 

Publication

Alzheimer’s disease: the amyloid hypothesis and the inverse warburg effect.

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Demetrius LA, Magistretti PJ, Pellerin L.

Front Physiol. 2015 Jan 14;5:522. doi: 10.3389/fphys.2014.00522. eCollection 2014.PMID: 25642192

 

Publication

Lactate promotes plasticity gene expression by potentiating nmda signaling in neurons.

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Yang J, Ruchti E, Petit JM, Jourdain P, Grenningloh G, Allaman I, Magistretti PJ.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12228-33. doi: 10.1073/pnas.1322912111. Epub 2014 Jul 28.PMID: 25071212

 

Publication

Hypertonic lactate and the injured brain: facts and the potential for positive clinical implications.

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Bouzat P, Magistretti PJ, Oddo M.

Intensive Care Med. 2014 Jun;40(6):920-1. doi: 10.1007/s00134-014-3312-x. Epub 2014 May 1. PMID: 24789621

 

Publication

2013

Cerebral extracellular lactate increase is predominantly nonischemic in patients with severe traumatic brain injury.

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M, Bloch J, Levivier M, Magistretti PJ, Meuli R, Oddo M.

J Cereb Blood Flow Metab. 2013 Nov;33(11):1815-22. doi: 10.1038/jcbfm.2013.142. Epub 2013 Aug 21.PMID: 23963367

 

Publication

Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice.

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Carneiro L, Favrod C, Preitner F, Thorens B, Stehle JC, Dix L, Pralong F, Magistretti PJ, Pellerin L.

PLoS One. 2013 Dec 18;8(12):e82505. doi: 10.1371/journal.pone.0082505. eCollection 2013.PMID: 24367518

 

Publication

Regulation of neurotrophic factors and energy metabolism by antidepressants in astrocytes.

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Martin JL, Magistretti PJ, Allaman I.

Curr Drug Targets. 2013 Oct;14(11):1308-21. PMID: 23469874

 

Publication

2012

Sweet sixteen for ANLS.

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Pellerin L, Magistretti PJ.

J Cereb Blood Flow Metab. 2012 Jul;32(7):1152-66. doi: 10.1038/jcbfm.2011.149. Epub 2011 Oct 26.PMID: 22027938

 

Publication

Oligodendroglia metabolically support axons and contribute to neurodegeneration.

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Lee Y, Morrison BM, Li Y, Lengacher S, Farah MH, Hoffman PN, Liu Y, Tsingalia A, Jin L, Zhang PW, Pellerin L, Magistretti PJ, Rothstein JD.

Nature. 2012 Jul 26;487(7408):443-8. doi: 10.1038/nature11314.PMID: 22801498

 

Publication

New evidence of neuroprotection by lactate after transient focal cerebral ischaemia

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Berthet C, Castillo X, Magistretti PJ, Hirt L.

Cerebrovasc Dis. 2012;34(5-6):329-35. doi: 10.1159/000343657. Epub 2012 Nov 14.PMID: 23154656

 

Publication

2011

Glutamate transport decreases mitochondrial ph and modulates oxidative metabolism in astrocytes.

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Azarias G, Perreten H, Lengacher S, Poburko D, Demaurex N, Magistretti PJ, Chatton JY.

J Neurosci. 2011 Mar 9;31(10):3550-9. doi: 10.1523/JNEUROSCI.4378-10.2011.PMID: 21389211

 

Publication

In vivo evidence for lactate as a neuronal energy source.

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Wyss MT, Jolivet R, Buck A, Magistretti PJ, Weber B.

J Neurosci. 2011 May 18;31(20):7477-85. doi: 10.1523/JNEUROSCI.0415-11.2011.PMID: 21593331

 

Publication

Altered glycogen metabolism in cultured astrocytes from mice with chronic glutathione deficit; relevance for neuroenergetics in schizophrenia.

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Lavoie S, Allaman I, Petit JM, Do KQ, Magistretti PJ.

PLoS One. 2011;6(7):e22875. doi: 10.1371/journal.pone.0022875. Epub 2011 Jul 28.PMID: 21829542

 

Publication

Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation.

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Bélanger M, Allaman I, Magistretti PJ.

Cell Metab. 2011 Dec 7;14(6):724-38. doi: 10.1016/j.cmet.2011.08.016. Review.PMID: 22152301

 

Publication

Neuron-glia metabolic coupling and plasticity.

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Magistretti PJ.

Exp Physiol. 2011 Apr;96(4):407-10. doi: 10.1113/expphysiol.2010.053157. Epub 2010 Dec 1.PMID: 21123364

 

Publication

Astrocyte-neuron metabolic relationships: for better and for worse.

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Belanger M, Allaman I, Magistretti PJ.

Trends Neurosci. 2011 Feb;34(2):76-87. doi: 10.1016/j.tins.2010.12.001. Epub 2011 Jan 13. PMID: 21236501

 

Publication

Astrocyte-neuron lactate transport is required for long-term memory formation.

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Suzuki A, Stern SA, Bozdagi O, Huntley GW, Walker RH, Magistretti PJ, Alberini CM.

Cell. 2011 Mar 4;144(5):810-23. doi: 10.1016/j.cell.2011.02.018.PMID: 21376239

 

Publication

2009

The role of astroglia in neuroprotection.

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Bélanger M, Magistretti PJ.

Dialogues Clin Neurosci. 2009;11(3):281-95.PMID: 19877496

 

Publication

Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability.

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Bélanger M, Magistretti PJ.

Dialogues Clin Neurosci. 2009;11(3):281-95.PMID: 19877496

 

Publication

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