Publications

2022

REPRESENTING STIMULUS INFORMATION IN AN ENERGY METABOLISM PATHWAY.

Coggan JS, Keller D, Markram H, Schürmann F, Magistretti PJ.

J Theor Biol. 2022 May 7;540:111090. doi: 10.1016/j.jtbi.2022.111090. Epub 2022 Mar 7


ASTROCYTES AS KEY REGULATORS OF BRAIN ENERGY METABOLSIM : NEW THERAPEUTIC PERSPECTIVES.

Beard E, Lengacher S, Dias S, Magistretti PJ, Finsterwald C.

Front Physiol. 2022 Jan 11;12:825816. doi: 10.3389/fphys.2021.825816. eCollection 2021.




2021

HYDROXYCARBOXYLIC ACID RECEPTOR 1 AND NEUROPROTECTION IN A MOUSE MODEL OF CEREBRAL ISCHEMIA-REPERFUSION

Buscemi L, Blochet C, Magistretti PJ, Hirt L,

Front. Physiol., 21 May 2021 | https://doi.org/10.3389/fphys.2021.689239


GANGLIOSIDE GM1 TARGETS ASTROCYTES TO STIMULATE CEREBRAL ENERGY METABOLISM

Finsterwald C, Dias S, Magistretti PJ, Lengacher S,

Front. Pharmacol., 28 April 2021 | https://doi.org/10.3389/fphar.2021.653842


REACTIVE OXYGEN SPECIES: BEYOND THEIR REACTIVE BEHAVIOR

Tauffenberger A, Magistretti PJ

Neurochem Res. 2021 Jan;46(1):77-87. doi: 10.1007/s11064-020-03208-7


ROLE OF ADULT HIPPOCAMPAL NEUROGENESIS IN THE ANTIDEPRESSANT ACTIONS OF LACTATE

Carrard A, Cassé F, Carron C, Burlet-Godinot S, Toni N, Magistretti PJ; Martin JL,

Nature, Mol. Psychiaatry 2021, https://doi.org/10.1038/s41380-021-01122-0


DIGITAL RECONSTRUCTION OF THE NEURO-GLIA-VASCULAR ARCHITECTURE

Zisis E, Keller D, Kanari L, Arnaudon A, Gevaert M, Delemontex T, Coste B, Foni A, Abdellah M, Calì C, Hess K, Magistretti PJ, Schürmann F, Markram H

Cerebral Cortex, bhab254, https://doi.org/10.1093/cercor/bhab254


L-LACTATE: FOOD FOR THOUGHTS, MEMORY AND BEHAVIOR

Veloz Castillo MF, Magistretti PJ, Cali, C,

Metabolites 2021, 11(8), 548; https://doi.org/10.3390/metabo11080548



2020

HOW LACTATE LINKS CANNABIS TO SOCIAL BEHAVIOUR

Pierre J. Magistretti

Nature 583, 526-527 (2020); doi: https://doi.org/10.1038/d41586-020-01975-5


GUT MICROBIOTA MODULATES EXPRESSION OF GENES INVOLVED IN THE ASTROCYTE-NEURON LACTATE SHUTTLE IN THE HIPPOCAMPUS

Margineanu M, Sherwin E, Golubeva A, Peterson V, Hoban A, Fiumellia H, Rea K, Cryan JF, Magistretti PJ

European Neuropsychopharmacology, Volume 41, December 2020, Pages 152-159, https://doi.org/10.1016/j.euroneuro.2020.11.006


ULTRASTRUCTURAL EVIDENCE FOR A ROLE OF ASTROCYTES AND GLYCOGEN-DERIVED LACTATE IN LEARNING-DEPENDENT SYNAPTIC STABILIZATION

Vezzoli E, Cali C, De Roo M, Ponzoni L, Sogne E, Gagnon N, Francolini M, Braida D, Sala M, Muller D, Falqui A, Magistretti PJ

Cereb Cortex. 2020 Apr 14;30(4):2114-2127. doi: 10.1093/cercor/bhz226.


EXCITATION STATES OF METABOLIC NETWORKS PREDICT DOSE-RESPONSE FINGERPRINTING AND LIGAND PULSE PHASE SIGNALLING

Coggan JS, Keller D, Markram H, Schurmann F, Magistretti PJ

J Theor Biol. 2020 Feb 21;487:110123. doi: 10.1016/j.jtbi.2019.110123



2019

LACTATE AND PYRUVATE PROMOTE OXIDATIVE STRESS RESISTANCE THROUGH HORMETIC ROS SIGNALING

Tauffenberger A, Fiumelli H, Alsmustafa S, Magistretti PJ

Cell Death Dis. 2019. PMID: 31506428


3D CELLULAR RECONSTRUCTION OF CORTICAL GLIA AND PARENCHYMAL MORPHOMETRIC ANALYSIS FROM SERIAL BLOCK-FACE ELECTRON MICROSCOPY OF JUVENILE RAT

Cali C, Agus M, Kare K, Boges DJ, Lehvaslaiho H, Hadwiger M, Magistretti PJ

Prog Neurobiol. 2019 Dec;183:101696. doi: 10.1016/j.pneurobio.2019.101696.


GANGLIOSIDES: TREATMENT AVENUES IN NEURODEGENERATIVE DISESAE

Magistretti PJ, Geisler FH, Schneider JS, Li PA, Fiumelli H, Sipione S

Front Neurol. 2019 Aug 6;10:859. doi: 10.3389/fneur.2019.00859.


2018

L-LACTATE REGULATES THE EXPRESSION OF SYNAPTIC PLASTICITY AND NEUROPROTECTION GENES IN CORTICAL NEURONS: A TRANSCRIPTOME ANALYSIS

Margineanu MB, Mahmood H, Fiumelli H, Magistretti PJ

Front Mol Neurosci. 2018 Oct 10;11:375. doi: 10.3389/fnmol.2018.00375. eCollection 2018. PMID: 30364173


A PROCESS FOR DIGITIZING AND STIMULATING BIOLOGICALLY REALISTIC OLIGOCELLULAR NETWORKS DEMONSTRATED FOR THE NEURO-GLIO-VASCULAR ENSEMBLE.

Coggan JS, Cali C, Keller D, Agus M, Boges D, Abdellah M, Kare K, Lehvaslaiho H, Eilemann S, Jolivet RB, Hadwiger M, Markram H, Schurmann F, Magistretti PJ

Front Neurosci. 2018 Sep 25;12:664. doi: 10.3389/fnins.2018.00664. eCollection 2018. PMID: 30319342


DUAL ACTION OF L-LACTATE ON THE ACTIVITY OF NR2B-CONTAINING NMDA RECEPTORS: FROM POTENTIATION TO NEUROPROTECTION

Jourdain P, Rothenfusser K, Ben-Abida C, Allaman I, Marquet P, Magistretti PJ

Sci Rep. 2018 Sep 7;8(1):13472. doi: 10.1038/s41598-018-31534-y. PMID: 30194439


NOREPINEPHRINE STIMULATES GLYCOGENOLYSIS IN ASTROCYTES TO FUEL NEURONS WITH LACTATE

Coggan JS, Keller D, Cali C, Lehvaslaiho H, Markram H, Schurmann F, Magistretti PJ

PLoS Comput Biol. 2018 Aug 30;14(8):e1006392. doi: 10.1371/journal.pcbi.1006392. eCollection 2018 Aug. PMID: 30161133


EXTRACELLULAR POTASSIUM AND GLUTAMATE INTERACT TO MODULATE MITOCHONDRIA IN ASTROCYTES

Rimmele TS, de Castro Abrantes H, Wellbourne-Wood J, Lengacher S, Chatton JY

ACS Chem Neurosci. 2018 Aug 15;9(8):2009-2015. doi: 10.1021/acschemneuro.8b00124. PMID: 29741354


HYPERPOLARIZED 13C MAGNETIC RESONANCE SPECTROSCOPY REVEALS THE RATE-LIMITING ROLE OF THE BLOOD-BRAIN BARRIER IN THE CEREBRAL UPTAKE AND METABOLISM OF L-LACTATE IN VIVO

Takado Y, Cheng T, Bastiaasen JAM, Yoshihara HAI, Lanz B, Mishkovsky M, Lengacher S, Comment A

ACS Chem Neurosci. 2018 May 25. doi: 10.1021/acschemneuro.8b00066. PMID: 29771492


HYPERTONIC LACTATE TO IMPROVE CEREBRAL PERFUSION AND GLUCOSE AVAILABILITY AFTER ACUTE BRAIN INJURY

Carteron L, Solari D, Patet C, Quintard H, Miroz JP, Bloch J, Daniel RT, Hirt L, Eckert P, Magistretti PJ and Oddo M

Crit Care Med. 2018 Jun 19. PMID: 29923931


LACTATE IN THE BRAIN: FROM METABOLIC END-PRODUCT TO SIGNALLING MOLECULE.

Magistretti PJ, Allaman I

Nat Rev Neurosci. 2018 Apr;19(4):235-249. doi: 10.1038/nrn.2018.19. PMID: 29515192


PERIPHERAL ADMINISTRATION OF LACTATE PROCUDES ANTIDEPRESSANT-LIKE EFFECT

Carrard A, Elsayed M, Margineanu M, Boury-Jamot B, Fragniere L, Meylan EM, Petit JM, Fiumelli H, Magistretti PJ, Martin JL.

Mol Psychiatry. 2018 Feb;23(2):488. doi: 10.1038/mp.2016.237. Epub 2016 Dec 6. PMID: 27922608

2017

INADEQUATE BRAIN GLYCOGEN OR SLEEP INCREASES SPREADING DEPRESSION SUSCEPTIBILITY

Kilic K, Karatas H, Donmez-Demir B, Eren-Kocak E, Gursoy-Ozdemir Y, Can A, Petit JM, Magistretti PJ, Dalkara T

Ann Neurol. 2017 Dec 15. doi: 10.1002/ana.25122. PMID: 29244233






2016

LACTATE RELEASE FOM ASTROCYTES TO NEURONS CONTRIBUTES TO COCAINE MEMORY FORMATION

Boury-Jamot B, Halgon O, Magistretti PJ, Boutrel B

Bioessays. 2016 Dec. doi: 10.1002/bies.201600118. PMID: 27699812


IN VIVO EVIDENCE FOR A LACTATE GRADIENT FROM ASTROCYTES TO NEURONS.

Mächler P, Wyss MT, Elsayed M, Stobart J, Gutierrez R, von Faber-Castell A, Kaelin V, Zuend M, San Martín A, Romero-Gómez I, Baeza-Lehnert F, Lengacher S, Schneider BL, Aebischer P, Magistretti PJ, Barros LF, Weber B.

Cell Metab. 2016 Jan 12;23(1):94-102. doi: 10.1016/j.cmet.2015.10.010. Epub 2015 Nov 19.PMID: 26698914


IMPROVEMENT OF NEUROENERGETICS BY HYPERTONIC LACTATE THERAPY IN PATIENTS WITH TRAUMATIC BRAIN INJURY IS DEPENDENT ON BASELINE CEREBRAL LACTATE/PYRUVATE RATIO.

Quintard H, Patet C, Zerlauth JB, Suys T, Bouzat P, Pellerin L, Meuli R, Magistretti PJ, Oddo M.

J Neurotrauma. 2016 Apr 1;33(7):681-7. doi: 10.1089/neu.2015.4057. Epub 2015 Dec 15.PMID: 26421521


DISRUPTING ASTROCYTE-NEURON LACTATE TRANSFER PERSISTENTLY REDUCES CONDITIONED RESPONSES TO COCAINE.

Boury-Jamot B, Carrard A, Martin JL, Halfon O, Magistretti PJ, Boutrel B.

Mol Psychiatry. 2016 Aug;21(8):1070-6. doi: 10.1038/mp.2015.157. Epub 2015 Oct 27.PMID: 26503760


REGULATION OF NEURON-ASTROCYTE METABOLIC COUPLING ACROSS THE SLEEP-WAKE CYCLE.

Petit JM, Magistretti PJ.

Neuroscience. 2016 May 26;323:135-56. doi: 10.1016/j.neuroscience.2015.12.007. Epub 2015 Dec 17.PMID: 26704637


L-LACTATE PROTECTS NEURONS AGAINST EXCITOTOXICITY: IMPLICATION OF AN ATP-MEDIATED SIGNALING CASCADE.

Jourdain P, Allaman I, Rothenfusser K, Fiumelli H, Marquet P, Magistretti PJ.

Sci Rep. 2016 Feb 19;6:21250. doi: 10.1038/srep21250.PMID: 26893204


SODIUM SIGNALING AND ASTROCYTE ENERGY METABOLISM.

Chatton JY, Magistretti PJ, Barros LF.

Glia. 2016 Mar 29. doi: 10.1002/glia.22971.Epub 2016 Mar 29.PMID: 27027636


A ROLE FOR LACTATE IN THE CONSOLIDATION OF DRUG-RELATED ASSOCIATIVE MEMORIES.

Boutrel B, Magistretti PJ.

Biol Psychiatry. 2016 Jun 1;79(11):875-7. doi: 10.1016/j.biopsych.2016.04.010.PMID: 27198521


IMAGING BRAIN AEROBIC GLYCOLYSIS AS A MARKER OF SYNAPTIC PLASTICITY.

Magistretti PJ

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7015-6. doi: 10.1073/pnas.1607423113. Epub 2016 Jun 17.PMID: 27317739


ASTROCYTIC BETA 2-ADRENERGIC RECEPTORS MEDIATE HIPPOCAMPAL LONG-TERM MEMORY CONSOLIDATION.

Gao V, Suzuki A, Magistretti PJ, Lengacher S, Pollonini G, Steinman MQ, Alberini CM.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8526-31. doi: 10.1073/pnas.1605063113. Epub 2016 Jul 8.PMID: 27402767


LACTATE RELEASE FROM ASTROCYTES TO NEURONS CONTRIBUTES TO COCAINE MEMORY FORMATION.

Boury-Jamot B, Halfon O, Magistretti PJ, Boutrel B.

Bioessays. 2016 Oct 4. doi: 10.1002/bies.201600118.PMID: 27699812


2015

DEFICIENCY IN MONOCARBOXYLATE TRANSPORTER 1 (MCT1) IN MICE DELAYS REGENERATION OF PERIPHERAL NERVES FOLLOWING SCIATIC NERVE CRUSH.

Morrison BM, Tsingalia A, Vidensky S, Lee Y, Jin L, Farah MH, Lengacher S, Magistretti PJ, Pellerin L, Rothstein JD.

Exp Neurol. 2015 Jan;263:325-38. doi: 10.1016/j.expneurol.2014.10.018. Epub 2014 Oct 29.PMID: 25447940


NEUROENERGETIC RESPONSE TO PROLONGED CEREBRAL GLUCOSE DEPLETION AFTER SEVERE BRAIN INJURY AND THE ROLE OF LACTATE.

Patet C, Quintard H, Suys T, Bloch J, Daniel RT, Pellerin L, Magistretti PJ, Oddo M.

J Neurotrauma. 2015 Oct 15;32(20):1560-6. doi: 10.1089/neu.2014.3781. Epub 2015 May 26.PMID: 25790152


A CELLULAR PERSPECTIVE ON BRAIN ENERGY METABOLISM AND FUNCTIONAL IMAGING.

Magistretti PJ, Allaman I.

Neuron. 2015 May 20;86(4):883-901. doi: 10.1016/j.neuron.2015.03.035. PMID: 25996133


ASTROCYTES: NEW TARGETS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES.

Finsterwald C, Magistretti PJ, Lengacher S.

Curr Pharm Des. 2015;21(25):3570-81. PMID: 26166612


LEARNING-INDUCED GENE EXPRESSION IN THE HIPPOCAMPUS REVEALS A ROLE OF NEURON -ASTROCYTE METABOLIC COUPLING IN LONG TERM MEMORY.

Tadi M, Allaman I, Lengacher S, Grenningloh G, Magistretti PJ.

PLoS One. 2015 Oct 29;10(10):e0141568. doi: 10.1371/journal.pone.0141568. eCollection 2015.PMID: 26513352


A NEW OUTLOOK ON MENTAL ILLNESSES: GLIAL INVOLVEMENT BEYOND THE GLUE.

Elsayed M, Magistretti PJ.

Front Cell Neurosci. 2015 Dec 16;9:468. doi: 10.3389/fncel.2015.00468. eCollection 2015. PMID: 26733803

2014

HYPERTONIC LACTATE AND THE INJURED BRAIN: FACTS AND THE POTENTIAL FOR POSITIVE CLINICAL IMPLICATIONS.

Bouzat P, Magistretti PJ, Oddo M.

Intensive Care Med. 2014 Jun;40(6):920-1. doi: 10.1007/s00134-014-3312-x. Epub 2014 May 1. PMID: 24789621


LACTATE PROMOTES PLASTICITY GENE EXPRESSION BY POTENTIATING NMDA SIGNALING IN NEURONS.

Yang J, Ruchti E, Petit JM, Jourdain P, Grenningloh G, Allaman I, Magistretti PJ.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12228-33. doi: 10.1073/pnas.1322912111. Epub 2014 Jul 28.PMID: 25071212


ALZHEIMER’S DISEASE: THE AMYLOID HYPOTHESIS AND THE INVERSE WARBURG EFFECT.

Demetrius LA, Magistretti PJ, Pellerin L.

Front Physiol. 2015 Jan 14;5:522. doi: 10.3389/fphys.2014.00522. eCollection 2014.PMID: 25642192


SYNAPTIC PLASTICITY AND THE WARBURG EFFECT.

Magistretti PJ.

Cell Metab. 2014 Jan 7;19(1):4-5. doi: 10.1016/j.cmet.2013.12.012.PMID: 24411936

2013

REGULATION OF NEUROTROPHIC FACTORS AND ENERGY METABOLISM BY ANTIDEPRESSANTS IN ASTROCYTES.

Martin JL, Magistretti PJ, Allaman I.

Curr Drug Targets. 2013 Oct;14(11):1308-21. PMID: 23469874


RESISTANCE TO DIET-INDUCED OBESITY AND ASSOCIATED METABOLIC PERTURBATIONS IN HAPLOINSUFFICIENT MONOCARBOXYLATE TRANSPORTER 1 MICE.

Lengacher S, Nehiri-Sitayeb T, Steiner N, Carneiro L, Favrod C, Preitner F, Thorens B, Stehle JC, Dix L, Pralong F, Magistretti PJ, Pellerin L.

PLoS One. 2013 Dec 18;8(12):e82505. doi: 10.1371/journal.pone.0082505. eCollection 2013.PMID: 24367518


CEREBRAL EXTRACELLULAR LACTATE INCREASE IS PREDOMINANTLY NONISCHEMIC IN PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY.

Sala N, Suys T, Zerlauth JB, Bouzat P, Messerer M, Bloch J, Levivier M, Magistretti PJ, Meuli R, Oddo M.

J Cereb Blood Flow Metab. 2013 Nov;33(11):1815-22. doi: 10.1038/jcbfm.2013.142. Epub 2013 Aug 21.PMID: 23963367

2012

NEW EVIDENCE OF NEUROPROTECTION BY LACTATE AFTER TRANSIENT FOCAL CEREBRAL ISCHAEMIA

EXTENDED BENEFIT AFTER INTRACEREBROVENTRICULAR INJECTION AND EFFICACY OF INTRAVENOUS ADMINISTRATION.

Berthet C, Castillo X, Magistretti PJ, Hirt L.

Cerebrovasc Dis. 2012;34(5-6):329-35. doi: 10.1159/000343657. Epub 2012 Nov 14.PMID: 23154656


OLIGODENDROGLIA METABOLICALLY SUPPORT AXONS AND CONTRIBUTE TO NEURODEGENERATION.

Lee Y, Morrison BM, Li Y, Lengacher S, Farah MH, Hoffman PN, Liu Y, Tsingalia A, Jin L, Zhang PW, Pellerin L, Magistretti PJ, Rothstein JD.

Nature. 2012 Jul 26;487(7408):443-8. doi: 10.1038/nature11314.PMID: 22801498


SWEET SIXTEEN FOR ANLS.

Pellerin L, Magistretti PJ.

J Cereb Blood Flow Metab. 2012 Jul;32(7):1152-66. doi: 10.1038/jcbfm.2011.149. Epub 2011 Oct 26.PMID: 22027938

2011

ASTROCYTE-NEURON LACTATE TRANSPORT IS REQUIRED FOR LONG-TERM MEMORY FORMATION.

Suzuki A, Stern SA, Bozdagi O, Huntley GW, Walker RH, Magistretti PJ, Alberini CM.

Cell. 2011 Mar 4;144(5):810-23. doi: 10.1016/j.cell.2011.02.018.PMID: 21376239


ASTROCYTE-NEURON METABOLIC RELATIONSHIPS: FOR BETTER AND FOR WORSE.

Belanger M, Allaman I, Magistretti PJ.

Trends Neurosci. 2011 Feb;34(2):76-87. doi: 10.1016/j.tins.2010.12.001. Epub 2011 Jan 13. PMID: 21236501


NEURON-GLIA METABOLIC COUPLING AND PLASTICITY.

Magistretti PJ.

Exp Physiol. 2011 Apr;96(4):407-10. doi: 10.1113/expphysiol.2010.053157. Epub 2010 Dec 1.PMID: 21123364


BRAIN ENERGY METABOLISM: FOCUS ON ASTROCYTE-NEURON METABOLIC COOPERATION.

Bélanger M, Allaman I, Magistretti PJ.

Cell Metab. 2011 Dec 7;14(6):724-38. doi: 10.1016/j.cmet.2011.08.016. Review.PMID: 22152301


ALTERED GLYCOGEN METABOLISM IN CULTURED ASTROCYTES FROM MICE WITH CHRONIC GLUTATHIONE DEFICIT; RELEVANCE FOR NEUROENERGETICS IN SCHIZOPHRENIA.

Lavoie S, Allaman I, Petit JM, Do KQ, Magistretti PJ.

PLoS One. 2011;6(7):e22875. doi: 10.1371/journal.pone.0022875. Epub 2011 Jul 28.PMID: 21829542


IN VIVO EVIDENCE FOR LACTATE AS A NEURONAL ENERGY SOURCE.

Wyss MT, Jolivet R, Buck A, Magistretti PJ, Weber B.

J Neurosci. 2011 May 18;31(20):7477-85. doi: 10.1523/JNEUROSCI.0415-11.2011.PMID: 21593331


GLUTAMATE TRANSPORT DECREASES MITOCHONDRIAL PH AND MODULATES OXIDATIVE METABOLISM IN ASTROCYTES.

Azarias G, Perreten H, Lengacher S, Poburko D, Demaurex N, Magistretti PJ, Chatton JY.

J Neurosci. 2011 Mar 9;31(10):3550-9. doi: 10.1523/JNEUROSCI.4378-10.2011.PMID: 21389211

2009

AMYLOID-BETA AGGREGATES CAUSE ALTERATIONS OF ASTROCYTIC METABOLIC PHENOTYPE: IMPACT ON NEURONAL VIABILITY.

Bélanger M, Magistretti PJ.

Dialogues Clin Neurosci. 2009;11(3):281-95.PMID: 19877496


THE ROLE OF ASTROGLIA IN NEUROPROTECTION.

Bélanger M, Magistretti PJ.

Dialogues Clin Neurosci. 2009;11(3):281-95.PMID: 19877496