Publications

Our research has been covered in leading peer-reviewed publications.

Find out more below.

Astrocyte-derived lactate in stress disorders

 

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2022

Lactate supply overtakes glucose when neural computational and cognitive loads scale up.

 

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Astrocytes as key regulators of brain energy metabolsim : new therapeutic perspectives.

 

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Representing stimulus information in an energy metabolism pathway.

 

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2021

L-lactate: food for thoughts, memory and behavior

 

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Digital reconstruction of the neuro-glia-vascular architecture

 

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Role of adult hippocampal neurogenesis in the antidepressant actions of lactate

 

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Reactive oxygen species: beyond their reactive behavior

 

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Ganglioside GM1 targets astrocytes to stimulate cerebral energy metabolism

 

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Hydroxycarboxylic acid receptor 1 and neuroprotection in a mouse model of cerebral ischemia-reperfusion

 

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2020

Excitation states of metabolic networks predict dose-response fingerprinting and ligand pulse phase signalling

 

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Ultrastructural evidence for a role of astrocytes and glycogen-derived lactate in learning-dependent synaptic stabilization

 

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Gut microbiota modulates expression of genes involved in the astrocyte-neuron lactate shuttle in the hippocampus

 

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How lactate links cannabis to social behaviour

 

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2019

Gangliosides: treatment avenues in neurodegenerative disease

 

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3D cellular reconstruction of cortical glia and parenchymal morphometric analysis from serial block-face electron microscopy of juvenile rat

 

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Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling

 

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2018

Peripheral administration of lactate procudes antidepressant-like effect

 

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Lactate in the brain: from metabolic end-product to signalling molecule.

 

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Hypertonic lactate to improve cerebral perfusion and glucose availability after acute brain injury

 

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Hyperpolarized 13C magnetic resonance spectroscopy reveals the rate-limiting role of the blood-brain barrier in the cerebral uptake and metabolism of l-lactate in vivo

 

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Extracellular potassium and glutamate interact to modulate mitochondria in astrocytes

 

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Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate

 

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Dual action of L-lactate on the activity of NR2B2-containing NMDA receptors: from potentiation to neuroprotection

 

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A process for digitizing and stimulating biologically realistic oligocellular networks demonstrated for the neuro-glio-vascular ensemble.

 

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L-lactate regulates the expression of synaptic plasticity and neuroprotection genes in cortical neurons: a transcriptome analysis

 

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2017

Inadequate brain glycogen or sleep increases spreading depression susceptibility

 

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2016

Lactate release from astrocytes to neurons contributes to cocaine memory formation.

 

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Astrocytic beta 2-adrenergic receptors mediate hippocampal long-term memory consolidation.

 

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Imaging brain aerobic glycolysis as a marker of synaptic plasticity.

 

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A role for lactate in the consolidation of drug-related associative memories.

 

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Sodium signaling and astrocyte energy metabolism.

 

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L-lactate protects neurons against excitotoxicity: implication of an atp-mediated signaling cascade.

 

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Regulation of neuron-astrocyte metabolic coupling across the sleep-wake cycle.

 

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Disrupting astrocyte-neuron lactate transfer persistently reduces conditioned responses to cocaine.

 

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Improvement of neuroenergetics by hypertonic lactate therapy in patients with traumatic brain injury is dependent on baseline cerebral lactate/pyruvate ratio.

 

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In vivo evidence for a lactate gradient from astrocytes to neurons.

 

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Lactate release fom astrocytes to neurons contributes to cocaine memory formation

 

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2015

A new outlook on mental illnesses: glial involvement beyond the glue.

 

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Learning-induced gene expression in the hippocampus reveals a role of neuron -astrocyte metabolic coupling in long term memory.

 

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Astrocytes: new targets for the treatment of neurodegenerative diseases.

 

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A cellular perspective on brain energy metabolism and functional imaging.

 

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Neuroenergetic response to prolonged cerebral glucose depletion after severe brain injury and the role of lactate.

 

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Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush.

 

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2014

Synaptic plasticity and the warburg effect.

 

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Alzheimer’s disease: the amyloid hypothesis and the inverse warburg effect.

 

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Lactate promotes plasticity gene expression by potentiating nmda signaling in neurons.

 

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Hypertonic lactate and the injured brain: facts and the potential for positive clinical implications.

 

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2013

Cerebral extracellular lactate increase is predominantly nonischemic in patients with severe traumatic brain injury.

 

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Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice.

 

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Regulation of neurotrophic factors and energy metabolism by antidepressants in astrocytes.

 

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2012

Sweet sixteen for ANLS.

 

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Oligodendroglia metabolically support axons and contribute to neurodegeneration.

 

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New evidence of neuroprotection by lactate after transient focal cerebral ischaemia

 

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2011

Glutamate transport decreases mitochondrial ph and modulates oxidative metabolism in astrocytes.

 

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In vivo evidence for lactate as a neuronal energy source.

 

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Altered glycogen metabolism in cultured astrocytes from mice with chronic glutathione deficit; relevance for neuroenergetics in schizophrenia.

 

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Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation.

 

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Neuron-glia metabolic coupling and plasticity.

 

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Astrocyte-neuron metabolic relationships: for better and for worse.

 

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Astrocyte-neuron lactate transport is required for long-term memory formation.

 

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2009

The role of astroglia in neuroprotection.

 

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Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability.

 

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